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KMID : 1142220100050010037
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Regulatory Research on Food, Drug & Cosmetic
2010 Volume.5 No. 1 p.37 ~ p.43
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Development of Analytical Method of Dichlorophen and Methylisothiazolinone in Cosmetics
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Kim Sang-Seop
Kim Do-Jung
Choi Myeong-Sin
Kim Mi-Jeong
Kwon Kyoung-Jin
Kim Jung-Soo
Kim Dae-Woo
Kim Dong-Sub
Choi Bo-Kyung
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Abstract
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The safety of cosmetics is getting important considering some safety-related issues. Since some ingredients in cosmetics may cause safety problems, such as skin allergy, it is important to comply with the quantity limit in the cosmetics by ‘the Notification on Designation of Cosmetics Ingredients’. Preservatives are inevitably used to prevent cosmetics from contamination by microorganisms. Due to the safety of preservatives, their usage has been regulated in cosmetics by Korea food and drug administration. And ‘Guideline for Analytical Method of Limited Ingredients in Cosmetics’ was developed to help industry and regulatory agencies to make sure of the safety of cosmetics currently marketed in Korea. Dichlorophen and methylisothiazolonone were listed in ‘The Notification on Designation of cosmetics ingredients’ in 2008 and were asked to develop the analytical method. So, NIFDS studied the analytical method of dichlorophen and methylisothiazolinone and got the validated analytical method. The purpose of this study is to update the Guideline for Analytical Method of Limited Ingredients in Cosmetics and to show how to develop the method with example of dichlorophen and methylisothiazolinone for this guideline.
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KEYWORD
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cosmetics, limited ingredients, guideline, preservative, analytical method
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